The Office for Human Research Protections (OHRP) has responsibility for oversight for the compliance of federal regulations for the protection of human research subjects as defined under 45 CFR Part 46, also known as the Common Rule. In carrying out this responsibility, OHRP reviews allegations of noncompliance involving human subject research projects that are either:

• Directly supported by the U.S. Department of Health and Human Services (HHS), or

• Being conducted at an institution that has an agreement in place under its Assurance of Compliance to provide OHRP jurisdiction over all research, regardless of source of support.  (This is a voluntary amendment to the Federal Wide Assurance Agreement (FWA) and is not required by institutions.)

National Prevention Strategy

HHS Home Page 

2020 - 2025 Strategic Plan

HHS - Home Page

Legal and Ethical Framework to Use Centers for Disease Control and Prevention Data for Patient-Centered Outcomes Research

Office of the Inspector General

Office of the Inspector General

National Opioids Crisis: Help and Resources

HHS PMTF Report

Office of the Inspector General - 2025 Strategic Plan

Office of the Inspector General OIG's Top Unimplemented Recommendations: Solutions to Reduce Fraud, Waste & Abuse in HHS Programs